Pair Name	Aloin, Metformin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Induction-->Autophagy
Gene Regulation	Up-regulation	Activity	AKT1	hsa207
	Up-regulation	Activity	MTOR	hsa2475
	Up-regulation	Activity	PIK3CA	hsa5290
In Vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens (Human)	CVCL_0027
	BEL-7402	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_5492
In Vivo Model	For xenograft study, mice were inoculated subcutaneously into the right-back with 7.5×10⁶ HepG2 cells in 200 μl PBS and Matrigel (1:1).
Result	Our research demonstrated that the concomitant treatment with aloin and MET enhances the antitumor effect by inhibiting the growth and invasion as well as inducing apoptosis and autophagy in HCC through PI3K/AKT/mTOR pathway.